GAMETIC DISEQUILIBRIUM IN MULTIGENIC SYSTEMS UNDER NORMALIZING SELECTION
نویسندگان
چکیده
منابع مشابه
Gametic Disequiilibrium in Multigenic Systems under Normalizing Selection1
HERE is a considerable literature on the occurrence of gametic disequilibrium T i n two locus system S. (See KIMURA 1956: LEWONTIN and KOJIMA 1960; KOJIMA and KELLEHER 1961; BODMER and PARSONS 1962; LEWONTIN 1964; KOJIMA 1965). A measure of gametic disequilibrium which has been frequently used is D > 0, coupling disequilibrium D = 0, gametic equilibrium D < 0, repulsion disequilibrium DLj = goo...
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Various measures have been proposed for characterizing the statistical association that arises between alleles at different loci. Hedrick has compared these measures with the standardized measure D' proposed by Lewontin on the grounds that this latter measure is independent of allele frequency. Although D' has the same range for all allelic frequencies, in fact, D' is not "independent" of allel...
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Five different measures of gametic disequilibrium in current use and a new one based on R. C. Lewontin's D', are examined and compared. All of them, except the measure based on Lewontin's D', are highly dependent upon allelic frequencies, including four measures that are normalized in some manner. In addition, the measures suggested by A. H. D. Brown, M. F. Feldman and E. Nevo, and T. Ohta can ...
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Likelihood methods are developed for the estimation and testing of multiple-locus gametic disequilibria, using log-linear models of parametric effects. The estimates of disquilibrium are related to Kimura's Z-measure, and may be extended to multiple alleles and multiple loci. Likelihood ratio test criteria are constructed, which are asymptotically distributed as chi(2). The analysis is partitio...
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ژورنال
عنوان ژورنال: Genetics
سال: 1967
ISSN: 1943-2631
DOI: 10.1093/genetics/55.3.507